Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance.
Τίτλος | Basal metabolic rate is decreased in women with polycystic ovary syndrome and biochemical hyperandrogenemia and is associated with insulin resistance. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Georgopoulos, N. A., Saltamavros A. D., Vervita V., Karkoulias K., Adonakis G., Decavalas G., Kourounis G., Markou K. B., & Kyriazopoulou V. |
Journal | Fertil Steril |
Volume | 92 |
Issue | 1 |
Pagination | 250-5 |
Date Published | 2009 Jul |
ISSN | 1556-5653 |
Λέξεις κλειδιά | Adult, Basal Metabolism, Body Composition, Female, Greece, Humans, Hyperandrogenism, Insulin Resistance, Polycystic Ovary Syndrome, Prospective Studies, Reference Values, Young Adult |
Abstract | OBJECTIVE: To evaluate basal metabolic rate (BMR) in women with PCOS and to determine its association with insulin resistance (IR).DESIGN: Prospective assessment of BMR in women with PCOS.SETTING: Outpatient clinic of the Division of Reproductive Endocrinology.PATIENT(S): The study included 91 Greek women with PCOS and biochemical hyperandrogenemia, with mean age 24.03 +/- 0.55 years and mean body mass index (BMI) 26.67 +/- 0.69 kg/m(2), and 48 matched regularly menstruating women, with mean age 26.33 +/- 0.93 years and mean BMI 23.35 +/- 0.85 kg/m(2), as control subjects.INTERVENTION(S): Assessment of BMR by indirect calorimetry, IR by HOMA and QUICKI indices, fasting insulin, and fasting glucose/insulin ratio.MAIN OUTCOME MEASURE(S): Reduced BMR in PCOS with or without IR.RESULT(S): Adjusted BMR was 1,868 +/- 41 kcal/day in the control group, 1,445.57 +/- 76 in all PCOS women, 1,590 +/- 130 in PCOS women without IR and 1,116 +/- 106 in PCOS women with IR. Adjusted BMR showed a statistically significant difference between women with PCOS and control subjects, with lowest values in the group of PCOS women with IR, even after adjusting all groups for age and BMI.CONCLUSION(S): Women with PCOS, particularly those with IR, present a significantly decreased BMR. |
DOI | 10.1016/j.fertnstert.2008.04.067 |
Alternate Journal | Fertil. Steril. |
PubMed ID | 18678372 |