Denosumab in treatment-naïve and pre-treated with zoledronic acid postmenopausal women with low bone mass: Effect on bone mineral density and bone turnover markers.
Τίτλος | Denosumab in treatment-naïve and pre-treated with zoledronic acid postmenopausal women with low bone mass: Effect on bone mineral density and bone turnover markers. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Anastasilakis, A. D., Polyzos S. A., Efstathiadou Z. A., Savvidis M., Sakellariou G. T., Papatheodorou A., Kokkoris P., & Makras P. |
Journal | Metabolism |
Volume | 64 |
Issue | 10 |
Pagination | 1291-7 |
Date Published | 2015 Oct |
ISSN | 1532-8600 |
Λέξεις κλειδιά | Biomarkers, Bone Density, Bone Density Conservation Agents, Bone Remodeling, Collagen Type I, Denosumab, Diphosphonates, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Imidazoles, Middle Aged, Osteoporosis, Postmenopausal, Peptide Fragments, Peptides, Postmenopause, Procollagen, RANK Ligand, Zoledronic Acid |
Abstract | PURPOSE: To compare denosumab-induced changes in lumbar spine (LS) and femoral neck (FN) bone mineral density (BMD), bone markers and free soluble receptor activator of nuclear factor kappaB ligand (sRANKL) between treatment naïve postmenopausal women with low bone mass (naïve group) and those who were previously treated with a single zoledronic acid infusion (post-Zol group). |
DOI | 10.1016/j.metabol.2015.06.018 |
Alternate Journal | Metab. Clin. Exp. |
PubMed ID | 26198440 |