Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome.
Τίτλος | Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Dambala, K., Paschou S. A., Michopoulos A., Siasos G., Goulis D. G., Vavilis D., & Tarlatzis B. C. |
Journal | Angiology |
Volume | 70 |
Issue | 9 |
Pagination | 797-801 |
Date Published | 2019 Oct |
ISSN | 1940-1574 |
Λέξεις κλειδιά | Biomarkers, Endothelium, Vascular, Female, Humans, Nicotinamide Phosphoribosyltransferase, Polycystic Ovary Syndrome, Vascular Diseases, Vascular Endothelial Growth Factor A |
Abstract | Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. The criteria required for the diagnosis identify various phenotypes, with different reproductive, metabolic, and cardiovascular (CV) risk characteristics. Emerging evidence links adipocyte-secreted hormones as candidates in the pathogenesis of endothelial dysfunction in PCOS, independently of additional risk factors. The aim of this review was to collect, analyze, and qualitatively resynthesize evidence on biomarkers of endothelial dysfunction (visfatin, vascular endothelial growth factor [VEGF], matrix metalloproteinase 9 [MMP-9]) in women with PCOS. Women with PCOS exhibit (a) increased plasma visfatin concentrations compared with controls with a similar body mass index; (b) increased VEGF production along with chronic, mild inflammation; and (c) increased MMP-9 concentrations, which might be related to either excessive CV risk or abnormalities of ovarian extracellular matrix remodeling, multiple cyst formation, follicular atresia, and chronic anovulation. As PCOS has been associated with CV risk, early identification of endothelial dysfunction is clinically relevant. |
DOI | 10.1177/0003319719840091 |
Alternate Journal | Angiology |
PubMed ID | 30969784 |