Protein and mRNA Expression Levels of Interleukin-17A, -17F and -22 in Blood and Skin Samples of Patients with Mycosis Fungoides.
Τίτλος | Protein and mRNA Expression Levels of Interleukin-17A, -17F and -22 in Blood and Skin Samples of Patients with Mycosis Fungoides. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Papathemeli, D., Patsatsi A., Papanastassiou D., Koletsa T., Papathemelis T., Avgeros C., Pikou O., Lazaridou E., & Georgiou E. |
Journal | Acta Derm Venereol |
Volume | 100 |
Issue | 18 |
Pagination | adv00326 |
Date Published | 2020 Nov 18 |
ISSN | 1651-2057 |
Abstract | This study investigated the expression of interleukin (IL)-17A, -17F and -22 in mycosis fungoides. Blood samples were collected from 50 patients with mycosis fungoides and 50 healthy controls. Skin samples were obtained from 26 patients with mycosis fungoides and 5 healthy controls. Protein levels of IL-17A, -17F and -22 were measured in serum by multiplex enzyme-linked immunosorbent assay, and mRNA expression levels were measured in blood and skin samples by real-time quantitative reverse transcription PCR. Both IL-17A and IL-17F mRNA expression levels were significantly lower in blood of patients with mycosis fungoides in comparison with healthy controls. IL-22 serum levels and expression levels of IL-22 mRNA in skin tissue, were significantly increased in patients with mycosis fungoides in comparison with healthy controls. These results suggest that low levels of IL-17A and IL-17F in mycosis fungoides may be connected to impaired immune surveillance contributing to tumourigenesis. Upregulation of IL-22 may play a role in the establishment of the tumour microenvironment in mycosis fungoides. |
DOI | 10.2340/00015555-3688 |
Alternate Journal | Acta Derm Venereol |
PubMed ID | 33170303 |