Autoantibodies predicting diabetes mellitus type I in celiac disease.
Τίτλος | Autoantibodies predicting diabetes mellitus type I in celiac disease. |
Publication Type | Journal Article |
Year of Publication | 1999 |
Authors | Galli-Tsinopoulou, A., Nousia-Arvanitakis S., Dracoulacos D., Xefteri M., & Karamouzis M. |
Journal | Horm Res |
Volume | 52 |
Issue | 3 |
Pagination | 119-24 |
Date Published | 1999 |
ISSN | 0301-0163 |
Λέξεις κλειδιά | Adolescent, Adult, Autoantibodies, Autoantigens, Celiac Disease, Child, Child, Preschool, Diabetes Mellitus, Type 1, Enzyme-Linked Immunosorbent Assay, Glutamate Decarboxylase, Glutens, Humans, Islets of Langerhans, Membrane Proteins, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatases, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Receptor-Like Protein Tyrosine Phosphatases, Class 8 |
Abstract | UNLABELLED: Celiac disease (CD) and diabetes mellitus type I (DM-I) are both autoimmune diseases. Abnormal first-phase insulin response (FPIR) is associated with the prediabetic phase. Glutamic acid decarboxylase (GAD) and islet cell antibodies (ICAs) - especially the tyrosine phosphatase-like protein IA-2 antibodies - are considered to be serological markers of DM-I future development. The aim of this study is to investigate the presence of autoantibodies (GAD, IA-2) in individuals with CD, on a gluten-free diet, who have normal intestinal morphology. Thirty patients with CD (4-22, mean 15 years), 30 newly diagnosed diabetic children (2.5-16, mean 10 years) and 30 healthy subjects (7-35, mean 18 years) were investigated. Serum GAD and IA-2 autoantibodies were assessed by a quantitative enzyme-linked immunosorbent assay (ELISA) method in all patients and controls. Seven CD patients (23%), 28 diabetic children (93%) and none in the control group had positive GAD and IA-2 antibodies. The FPIR was normal in CD patients (>/=46 mU/l). |
DOI | 10.1159/000023447 |
Alternate Journal | Horm Res |
PubMed ID | 10725775 |