Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel.
Τίτλος | Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Ibanez, B., Aletras A. H., Arai A. E., Arheden H., Bax J., Berry C., Bucciarelli-Ducci C., Croisille P., Dall'Armellina E., Dharmakumar R., Eitel I., Fernández-Jiménez R., Friedrich M. G., García-Dorado D., Hausenloy D. J., Kim R. J., Kozerke S., Kramer C. M., Salerno M., Sánchez-González J., Sanz J., & Fuster V. |
Journal | J Am Coll Cardiol |
Volume | 74 |
Issue | 2 |
Pagination | 238-256 |
Date Published | 2019 07 16 |
ISSN | 1558-3597 |
Λέξεις κλειδιά | Biomedical Research, Cardiac Imaging Techniques, Clinical Trials as Topic, Heart, Humans, Magnetic Resonance Imaging, Myocardial Infarction, Myocardial Reperfusion, Postoperative Period |
Abstract | After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characterization. CMR is also the preferred methodology for the identification of potential benefits associated with new cardioprotective strategies both in experimental and clinical trials. However, there is a wide heterogeneity in CMR methodologies used in experimental and clinical trials, including time of post-MI scan, acquisition protocols, and, more importantly, selection of endpoints. There is a need for standardization of these methodologies to improve the translation into a real clinical benefit. The main objective of this scientific expert panel consensus document is to provide recommendations for CMR endpoint selection in experimental and clinical trials based on pathophysiology and its association with hard outcomes. |
DOI | 10.1016/j.jacc.2019.05.024 |
Alternate Journal | J Am Coll Cardiol |
PubMed ID | 31296297 |
PubMed Central ID | PMC7363031 |
Grant List | FS/13/71/30378 / BHF_ / British Heart Foundation / United Kingdom R01 HL133407 / HL / NHLBI NIH HHS / United States R01 HL136578 / HL / NHLBI NIH HHS / United States R01 HL147133 / HL / NHLBI NIH HHS / United States |