Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonates.
Τίτλος | Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonates. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Sarafidis, K., Soubasi-Griva V., Piretzi K., Thomaidou A., Agakidou E., Taparkou A., Diamanti E., & Drossou-Agakidou V. |
Journal | Intensive Care Med |
Volume | 36 |
Issue | 5 |
Pagination | 864-8 |
Date Published | 2010 May |
ISSN | 1432-1238 |
Λέξεις κλειδιά | Biological Markers, Early Diagnosis, Enzyme-Linked Immunosorbent Assay, Humans, Infant, Newborn, Infant, Newborn, Diseases, Intensive Care Units, Neonatal, Interleukin-6, Membrane Glycoproteins, Prospective Studies, Receptors, Immunologic, Sensitivity and Specificity, Sepsis |
Abstract | OBJECTIVE: To assess the value of serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for early diagnosis of late-onset sepsis (LOS) in neonates, compared with interleukin-6 (IL-6).DESIGN AND SETTING: Prospective, observational study in a single, level III neonatal intensive care unit of a university hospital.PATIENTS: Fifty-two preterm and term neonates evaluated for suspected LOS were studied. Neonates were classified into two groups: infected [confirmed sepsis (n = 22) and possible sepsis (n = 9)] and noninfected neonates (n = 21).MEASUREMENTS AND RESULTS: Serum sTREM-1 and IL-6 were measured (enzyme-linked immunosorbent assays) when signs suggestive of sepsis emerged. Infected neonates had significantly higher sTREM-1 (p = 0.004) and IL-6 (p < 0.0001) than noninfected neonates. Receiver operating characteristic (ROC) curve analysis resulted in significant areas under the curve (AUC) for both sTREM-1 (AUC = 0.733, p = 0.005) and IL-6 (AUC = 0.892, p = 0.001) for identification of infected neonates, with the difference between the two AUC not being significant. Further analysis documented acceptable diagnostic performance of sTREM-1 and IL-6, which was not improved, however, when the two markers were combined.CONCLUSIONS: Serum sTREM-1 increases in infected neonates. Diagnostic accuracy of sTREM-1 either alone or in combination with IL-6 is not better than that of IL-6. |
DOI | 10.1007/s00134-010-1819-3 |
Alternate Journal | Intensive Care Med |
PubMed ID | 20232048 |