Elevated intraocular pressure in patients with acromegaly.
Τίτλος | Elevated intraocular pressure in patients with acromegaly. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Quaranta, L., Riva I., Mazziotti G., Porcelli T., Floriani I., Katsanos A., Giustina A., & Konstas A. G. P. |
Journal | Graefes Arch Clin Exp Ophthalmol |
Volume | 252 |
Issue | 7 |
Pagination | 1133-9 |
Date Published | 2014 Jul |
ISSN | 1435-702X |
Λέξεις κλειδιά | Acromegaly, Adult, Aged, Case-Control Studies, Cornea, Corneal Pachymetry, Female, Growth Hormone, Humans, Insulin-Like Growth Factor I, Intraocular Pressure, Male, Middle Aged, Organ Size, Tonometry, Ocular |
Abstract | PURPOSE: To evaluate central corneal thickness (CCT) and intraocular pressure (IOP) in a cohort of acromegalic patients, and to correlate CCT with serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).METHODS: Consecutive patients affected by acromegaly underwent a comprehensive endocrinological and ophthalmological evaluation, including serum GH and IGF-1 levels, CCT measured with ultrasonic pachymetry and IOP assessed with Goldmann applanation tonometry.RESULTS: Fourteen patients with acromegaly and 28 healthy controls were included in the study. Acromegalic patients had a statistically higher median CCT (570 μm [range 551.5-638] vs 542.7 μm [range 461.5-610]; p < 0.01) and higher median IOP (17.2 mm Hg [range 14-21] vs 13.7 mm Hg [range 10.5-19]; p < 0.01) than healthy controls. No statistically significant correlation was found among CCT and GH, CCT and IGF-1, IOP and GH, IOP and IGF-1 in the acromegalic group, whereas a statistically significant correlation was documented between CCT and IOP in the entire cohort (Spearman's correlation coefficient: 0.56, p < 0.01). However, when IOP was corrected for CCT no significant difference was found between the two study groups (p = 0.07).CONCLUSIONS: Our results suggest that acromegaly is associated with an increased CCT, which could lead to an overestimation of IOP readings as determined with Goldmann applanation tonometry. |
DOI | 10.1007/s00417-014-2650-2 |
Alternate Journal | Graefes Arch. Clin. Exp. Ophthalmol. |
PubMed ID | 24817254 |