Live birth rates using conventional in vitro fertilization compared to intracytoplasmic sperm injection in Bologna poor responders with a single oocyte retrieved.
Τίτλος | Live birth rates using conventional in vitro fertilization compared to intracytoplasmic sperm injection in Bologna poor responders with a single oocyte retrieved. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Sfontouris, I. A., Kolibianakis E. M., Lainas G. T., Navaratnarajah R., Tarlatzis B. C., & Lainas T. G. |
Journal | J Assist Reprod Genet |
Volume | 32 |
Issue | 5 |
Pagination | 691-7 |
Date Published | 2015 May |
ISSN | 1573-7330 |
Λέξεις κλειδιά | Adult, Birth Rate, Embryo Transfer, Embryo, Mammalian, Female, Fertilization in Vitro, Humans, Infertility, Female, Male, Oocytes, Ovulation Induction, Pregnancy, Prognosis, Retrospective Studies, Sperm Injections, Intracytoplasmic |
Abstract | PURPOSE: To compare reproductive outcomes following conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in poor responders fulfilling the Bologna criteria, with a single oocyte retrieved.METHODS: The present retrospective study included 243 Bologna poor responders with a single oocyte retrieved, who were categorized into three groups, depending on the fertilization method and semen quality (IVF non-male factor-IVF/NMF n = 101; ICSI non-male factor ICSI/NMF n = 50; ICSI male factor-ICSI/MF n = 92).RESULTS: In IVF/NMF, ICSI/NMF and ICSI/MF similar fertilization rates [65.3, 66, 58.7%, respectively], proportions of embryo formation [63.4, 60, 53.3%, respectively], proportions of good quality embryos [54.7, 56.7, 57.1%, respectively], implantation rates [8.9, 10, 8.2% respectively] and live birth rates per oocyte retrieval [5.0, 4.0, 3.3%, respectively] were observed. Degeneration rate of oocytes due to mechanical damage was significantly higher after ICSI in the ICSI/NMF and ICSI/MF groups (8 and 6.5%, respectively) compared to IVF/NMF (0%) (p = 0.02).CONCLUSIONS: Conventional IVF and ICSI are associated with similar reproductive outcomes in poor responder patients with a single oocyte retrieved. Therefore, the choice of fertilization method should be based primarily on semen quality, in combination with the patient's previous history. A randomized controlled trial should be performed to confirm this study's findings that conventional IVF and ICSI have similar reproductive outcomes in poor responders. |
DOI | 10.1007/s10815-015-0459-5 |
Alternate Journal | J. Assist. Reprod. Genet. |
PubMed ID | 25758990 |
PubMed Central ID | PMC4429441 |