Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial.
Τίτλος | Novasure impedance control system versus microwave endometrial ablation for the treatment of dysfunctional uterine bleeding: a double-blind, randomized controlled trial. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Athanatos, D., Pados G., Venetis C. A., Stamatopoulos P., Rousso D., Tsolakidis D., Stamatopoulos C. P., & Tarlatzis B. C. |
Journal | Clin Exp Obstet Gynecol |
Volume | 42 |
Issue | 3 |
Pagination | 347-51 |
Date Published | 2015 |
ISSN | 0390-6663 |
Λέξεις κλειδιά | Adult, Amenorrhea, Catheter Ablation, Double-Blind Method, Electric Impedance, Endometrial Ablation Techniques, Female, Humans, Menorrhagia, Metrorrhagia, Microwaves, Middle Aged, Treatment Outcome |
Abstract | PURPOSE OF INVESTIGATION: To compare the efficacy and safety of two different second-generation ablation devices, Novasure impedance control system and microwave endometrial ablation (MEA), in cases of abnormal uterine bleeding (AUB).MATERIALS AND METHODS: This is a randomized controlled trial that took place in a single Gynecological Department of a University Hospital. Sixty-six women with dysfunctional uterine bleeding (DUB), unresponsive to medical treatment, were included in the trial. The ratio of women allocated to bipolar radio-frequency ablation or MEA was 1:1. Follow-up assessments were carried out at three and 12 months post-ablation. The present main outcome measure was amenorrhea rates 12-months post-treatment.RESULTS: The rate of amenorrhea at 12-months post-ablation was significantly higher in women treated by Novasure (25/33; 75.8%) as compared to those treated by MEA (8/33; 24.2%) (rate difference: +51.5%, 95% CI: +27.8 to +67.7).CONCLUSION: In women with DUB, endometrial ablation with Novasure bipolar radiofrequency impedance-controlled system is associated with increased rates of amenorrhea at 12-months post-treatment as compared to the MEA method. |
Alternate Journal | Clin Exp Obstet Gynecol |
PubMed ID | 26152008 |