The impact of transmission-emission misregistration on the interpretation of SPET/CT myocardial perfusion studies and the value of misregistration correction.
Τίτλος | The impact of transmission-emission misregistration on the interpretation of SPET/CT myocardial perfusion studies and the value of misregistration correction. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Apostolopoulos, D. J., Gąsowska M., Savvopoulos C. A., Skouras T., Spyridonidis T., Andrejczuk A., & Vassilakos P. J. |
Journal | Hell J Nucl Med |
Volume | 18 |
Issue | 2 |
Pagination | 114-21 |
Date Published | 2015 May-Aug |
ISSN | 1790-5427 |
Λέξεις κλειδιά | Artifacts, Coronary Artery Disease, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Male, Middle Aged, Multimodal Imaging, Myocardial Perfusion Imaging, Reproducibility of Results, Sensitivity and Specificity, Subtraction Technique, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed |
Abstract | OBJECTIVE: Previous studies indicate that the quality of single photon emission tomography/computed tomography (SPET/CT) myocardial perfusion imaging (MPI) is degraded by even mild transmission-emission misregistrations. The purpose of the current study was to investigate the impact of SPET/CT misalignment on the interpretation of MPI and examine the value of a commercial software application for registration correction.SUBJECTS AND METHODS: A total of 255 technetium-99m ((99m)Tc)-tetrofosmin stress/rest MPI examinations in 150 patients were reviewed for SPET/CT misalignment. After registration correction by the software, images were reassessed for interpretation differences from the misregistered study. The diagnostic benefit of reregistration was determined by taking into account the non-attenuation compensated image pattern, combined stress-rest evaluation, gated-SPET data and patient's history. In a phantom experiment and in 3 representative clinical cases, SPET/CT misalignment was purposely created by the software by sequential slice shifts and its effect was evaluated quantitatively.RESULTS: Misregistration ≥1 pixel in at least one direction was observed in 24% of studies. Interpretation of MPI changed after registration correction in 11% of cases with misalignment <1 pixel, in 18% with 1-2 and in 73% with ≥2 pixels. The diagnostic information seemed to improve after registration correction in 58% of studies irrespective of the degree of misregistration. Software-simulated misregistration had dissimilar effects in the phantom and the 3 selected clinical cases.CONCLUSIONS: The impact of SPET/CT misregistration on MPI interpretation although influenced by the degree and direction of slice misplacement, it is also case-specific and hardly predictable. Registration restoration by the software seems worthwhile regardless of misregistration magnitude. |
DOI | 10.1967/s002449910205 |
Alternate Journal | Hell J Nucl Med |
PubMed ID | 26187210 |