Association between cardiotrophin 1 levels and central blood pressure in untreated patients with essential hypertension.
Τίτλος | Association between cardiotrophin 1 levels and central blood pressure in untreated patients with essential hypertension. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Gkaliagkousi, E., Gavriilaki E., Nikolaidou B., Chatzopoulou F., Anyfanti P., Triantafyllou A., Petidis K., Zamboulis C., & Douma S. |
Journal | Am J Hypertens |
Volume | 27 |
Issue | 5 |
Pagination | 651-5 |
Date Published | 2014 May |
ISSN | 1941-7225 |
Λέξεις κλειδιά | Adult, Biomarkers, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Case-Control Studies, Cytokines, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hypertension, Male, Manometry, Middle Aged, Predictive Value of Tests, Prognosis, Pulse Wave Analysis, Up-Regulation, Vascular Stiffness |
Abstract | BACKGROUND: Cardiotrophin 1 (CT-1) is an interleukin 6-related cytokine recently implicated in cardiac hypertrophy and vascular damage in essential hypertension (EH). We aimed first to determine CT-1 levels in naive, untreated patients with grade I EH (UH) as compared with normotensive (NT) individuals and, second, to investigate a possible association of CT-1 levels with indices of arterial stiffness.METHODS: We enrolled 45 consecutive untreated patients recently diagnosed with grade I EH by means of office and ambulatory blood pressure (BP) measurements and 25 age- and sex-matched NT subjects. CT-1 levels were measured with a commercially available enzyme-linked immunosorbent assay kit, and indices of arterial stiffness were determined by applanation tonometry.RESULTS: CT-1 levels were significantly elevated in UH patients compared with NT subjects (P < 0.001). Furthermore, CT-1 levels correlated positively with office, ambulatory and central BP. A significant bivariable correlation was also found between CT-1 levels and pulse wave velocity (P = 0.02). In the multivariable analysis, central systolic and diastolic BP proved the only significant predictors of CT-1 levels after controlling for other related factors.CONCLUSIONS: To our knowledge, this is the first study that correlates CT-1 levels with ambulatory and central BP, as well as with pulse wave velocity in patients with essential hypertension. Thus, studying the effects of CT-1 in the cardiovascular system in patients with EH represents a promising area of investigation in the future. |
DOI | 10.1093/ajh/hpt238 |
Alternate Journal | Am J Hypertens |
PubMed ID | 24401751 |