Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition.
Τίτλος | Bcl-2 overexpression in thyroid carcinoma cells increases sensitivity to Bcl-2 homology 3 domain inhibition. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Mitsiades, C. S., Hayden P., Kotoula V., McMillin D. W., McMullan C., Negri J., Delmore J. E., Poulaki V., & Mitsiades N. |
Journal | J Clin Endocrinol Metab |
Volume | 92 |
Issue | 12 |
Pagination | 4845-52 |
Date Published | 2007 Dec |
ISSN | 0021-972X |
Λέξεις κλειδιά | Antibiotics, Antineoplastic, Antineoplastic Agents, BH3 Interacting Domain Death Agonist Protein, Blotting, Western, Boronic Acids, Bortezomib, Carcinoma, Carcinoma, Medullary, Cell Line, Tumor, Colorimetry, Doxorubicin, Genes, bcl-2, Humans, Membrane Potentials, Oncogene Protein v-akt, Protease Inhibitors, Pyrazines, RNA, Neoplasm, Tetrazolium Salts, Thiazoles, Thyroid Neoplasms, Transcription, Genetic |
Abstract | CONTEXT: The Bcl-2 family of proteins regulates apoptosis in various models and may represent a promising therapeutic target in human malignancies. |
DOI | 10.1210/jc.2007-0942 |
Alternate Journal | J Clin Endocrinol Metab |
PubMed ID | 17848408 |