Biology of neurotensin: revisited study.
Τίτλος | Biology of neurotensin: revisited study. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Katsanos, G. S., Anogianaki A., Castellani M. L., Ciampoli C., De Amicis D., Orso C., Pollice R., Vecchiet J., Tetè S., Salini V., Caraffa A., Patruno A., Shaik Y. B., Kempuraj D., Doyle R., Antinolfi P. L., Cerulli G., Conti C. M., Fulcheri M., Neri G., & Sabatino G. |
Journal | Int J Immunopathol Pharmacol |
Volume | 21 |
Issue | 2 |
Pagination | 255-9 |
Date Published | 2008 Apr-Jun |
ISSN | 0394-6320 |
Λέξεις κλειδιά | Animals, Behavior, Brain Chemistry, Gastrointestinal Tract, Humans, Neurotensin, Neurotransmitter Agents, Tissue Distribution |
Abstract | The tridecapeptide neurotensin (NT) acts in the mammalian brain as a primary neurotransmitter or neuromodulator of classical neurotransmitters. Morphological and functional in vitro and in vivo studies have demonstrated the existence of close interactions between NT and dopamine both in limbic and in striatal brain regions. Additionally, biochemical and neurochemical evidence indicates that in these brain regions NT also plays a crucial role in the regulation of the aminoacidergic signalling. Immune cells, such as lymphocytes, macrophages and mast cells are reported to be activated by neuropeptides, such as neurotensin; this activation leads to cytokine and immunoglobulin production. In addition, neurotensin increases calcium level and the production of nitric oxide. Therefore neurotensin is deeply involved in immunity and inflammation but its real function still remains to be elucidated. |
DOI | 10.1177/039463200802100201 |
Alternate Journal | Int J Immunopathol Pharmacol |
PubMed ID | 18547468 |