Caspofungin at catheter lock concentrations eradicates mature biofilms of Candida lusitaniae and Candida guilliermondii.
| Τίτλος | Caspofungin at catheter lock concentrations eradicates mature biofilms of Candida lusitaniae and Candida guilliermondii. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Simitsopoulou, M., Kyrpitzi D., Velegraki A., Walsh T. J., & Roilides E. |
| Journal | Antimicrob Agents Chemother |
| Volume | 58 |
| Issue | 8 |
| Pagination | 4953-6 |
| Date Published | 2014 Aug |
| ISSN | 1098-6596 |
| Λέξεις κλειδιά | Amphotericin B, Antifungal Agents, Biofilms, Candida, Candida albicans, Catheters, Echinocandins, Humans, Lipopeptides, Microbial Sensitivity Tests, Plankton |
| Abstract | The antibiofilm activities of caspofungin, anidulafungin, micafungin, and liposomal amphotericin B were studied against Candida lusitaniae, Candida guilliermondii, and a Candida albicans control strain. While anidulafungin and micafungin (0.007 to 2,048 mg/liter) showed reduced activity against biofilms of both test species, caspofungin displayed concentration-dependent antibiofilm activity, reaching complete and persistent eradication at concentrations achievable during lock therapy (512 to 2,048 mg/liter, P < 0.05). Although liposomal amphotericin B strongly inhibited mature biofilms, it possessed lower antibiofilm activity than caspofungin (P < 0.05). |
| DOI | 10.1128/AAC.03117-14 |
| Alternate Journal | Antimicrob. Agents Chemother. |
| PubMed ID | 24890585 |
| PubMed Central ID | PMC4136003 |
