Cell-mediated immunity in human brucellosis.
| Τίτλος | Cell-mediated immunity in human brucellosis. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Skendros, P., Pappas G., & Boura P. |
| Journal | Microbes Infect |
| Volume | 13 |
| Issue | 2 |
| Pagination | 134-42 |
| Date Published | 2011 Feb |
| ISSN | 1769-714X |
| Λέξεις κλειδιά | Antigen-Presenting Cells, Brucella, Brucellosis, Dendritic Cells, Humans, Immunity, Cellular, Macrophages |
| Abstract | Brucella can parasitize within human antigen-presenting cells modifying phagocytosis, phagolysosome fusion, antigen presentation, cytokine secretion, and apoptosis. Subversion of innate immune mechanisms by Brucella leads to defective Th1 immune responses and T-cell anergy in chronic brucellosis patients. This review summarizes the cellular immune responses in brucellosis, based on data derived exclusively from human cells or cell lines. |
| DOI | 10.1016/j.micinf.2010.10.015 |
| Alternate Journal | Microbes Infect. |
| PubMed ID | 21034846 |
