Chemokine CXCL-1 expression in the subretinal fluid during rhegmatogenous retinal detachment.
| Τίτλος | Chemokine CXCL-1 expression in the subretinal fluid during rhegmatogenous retinal detachment. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Symeonidis, C., Androudi S., Rotsos T., Moschos M. M., Souliou E., Dimitrakos S. A., & Diza E. |
| Journal | Ocul Immunol Inflamm |
| Volume | 22 |
| Issue | 6 |
| Pagination | 449-53 |
| Date Published | 2014 Dec |
| ISSN | 1744-5078 |
| Λέξεις κλειδιά | Adult, Aged, Aged, 80 and over, Biomarkers, Chemokine CXCL1, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retinal Detachment, Subretinal Fluid, Vitreoretinopathy, Proliferative, Young Adult |
| Abstract | PURPOSE: To investigate the expression of chemokine CXCL-1 in the subretinal fluid (SRF) during rhegmatogenous retinal detachment (RRD) and identify potential correlations with number of quadrants involved and duration of the detachment.METHODS AND RESULTS: Inclusion criteria were patients aged 18 years or older and primary RRD possibly complicated by proliferative vitreoretinopathy (PVR). CXCL-1 levels were measured in 36 SRF samples from 36 RRD patients. Mean CXCL-1 levels (102 ± 37 pg/mL) were significantly higher (p = 0.050) compared to controls. CXCL-1 levels correlated significantly with age (p = 0.001) and RRD duration (p = 0.002). Maximum CXCL-1 levels coincided with total RRD, 29- to 60-day duration and PVR grade C.CONCLUSIONS: The findings of this study may contribute to increased understanding regarding the role of CXCL-1 during the onset and progression of the wound healing process in the context of RRD and PVR. |
| DOI | 10.3109/09273948.2013.863942 |
| Alternate Journal | Ocul. Immunol. Inflamm. |
| PubMed ID | 24354433 |
