Circulating platelet-derived microparticles are elevated in women with polycystic ovary syndrome diagnosed with the 1990 criteria and correlate with serum testosterone levels.
Τίτλος | Circulating platelet-derived microparticles are elevated in women with polycystic ovary syndrome diagnosed with the 1990 criteria and correlate with serum testosterone levels. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Koiou, E., Tziomalos K., Katsikis I., Kalaitzakis E., Kandaraki E. A., Tsourdi E. A., Delkos D., Papadakis E., & Panidis D. |
Journal | Eur J Endocrinol |
Volume | 165 |
Issue | 1 |
Pagination | 63-8 |
Date Published | 2011 Jul |
ISSN | 1479-683X |
Λέξεις κλειδιά | Adult, Blood Platelets, Cell-Derived Microparticles, Cross-Sectional Studies, Female, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Testosterone |
Abstract | OBJECTIVE: Women with polycystic ovary syndrome (PCOS) appear to have higher cardiovascular risk than healthy population. Patients diagnosed with PCOS according to the 1990 criteria have a more adverse metabolic profile than those diagnosed with the 2003 criteria. Platelet-derived microparticles (PMPs) appear to contribute to atherosclerosis but have not been assessed in PCOS. The aim of this study was to determine plasma PMPs in PCOS patients. Design A cross-sectional study.METHODS: We assessed plasma PMPs in 76 normal weight women with PCOS (39 belonging to the phenotypes 1 and 2 (group I) and 37 belonging to the phenotypes 3 and 4 (group II)) and 21 healthy normal weight women.RESULTS: Markers of obesity and insulin resistance did not differ between women with PCOS and controls. Serum testosterone levels and the free androgen index (FAI) were higher in group I than in group II and controls (P<0.001 for all comparisons) but did not differ between the latter two groups. Plasma PMPs were higher in group I than in controls (P=0.018) but did not differ between group II and controls or between groups I and II. In the total study population (n=97), plasma PMPs correlated with serum testosterone levels (r=0.207, P=0.042) and the FAI (r=0.207, P=0.042).CONCLUSIONS: Plasma PMPs are elevated in women with phenotypes 1 and 2 of PCOS compared with healthy controls, but not in women with phenotypes 3 and 4. Hyperandrogenemia, which is more pronounced in phenotypes 1 and 2, appears to be implicated in the increase in plasma PMPs. |
DOI | 10.1530/EJE-11-0144 |
Alternate Journal | Eur. J. Endocrinol. |
PubMed ID | 21543377 |