Clinical implications of congenital uterine anomalies: a meta-analysis of comparative studies.
Τίτλος | Clinical implications of congenital uterine anomalies: a meta-analysis of comparative studies. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Venetis, C. A., Papadopoulos S. P., Campo R., Gordts S., Tarlatzis B. C., & Grimbizis G. F. |
Journal | Reprod Biomed Online |
Volume | 29 |
Issue | 6 |
Pagination | 665-83 |
Date Published | 2014 Dec |
ISSN | 1472-6491 |
Λέξεις κλειδιά | Abortion, Spontaneous, Female, Humans, Hysteroscopy, Models, Statistical, Pregnancy, Pregnancy Outcome, Premature Birth, Risk Assessment, Urogenital Abnormalities, Uterus |
Abstract | The clinical implications of congenital uterine anomalies (CUA), and the benefits of hysteroscopic resection of a uterine septum, were evaluated. Studies comparing reproductive and obstetric outcome of patients with and without CUA and of patients who had and had not undergone hysteroscopic resection of a uterine septum, were evaluated. Meta-analysis of studies indicated that the pregnancy rate was decreased in women with CUA (RR 0.85, 95% CI 0.73 to 1.00; marginally significant finding, P = 0.05). The spontaneous abortion rate was increased in women with CUA (RR 1.68, 95% CI 1.31 to 2.15). Preterm delivery rates (RR 2.21, 95% CI 1.59 to 3.08), malpresentation at delivery (RR 4.75, 95% CI 3.29 to 6.84), low birth weight (RR 1.93, 95% CI 1.50 to 2.49) and perinatal mortality rates (RR 2.43, 95% CI 1.34 to 4.42) were significantly higher in women with CUA. Hysteroscopic removal of a septum was associated with a reduced probability of spontaneous abortion (RR 0.37, 95% CI 0.25 to 0.55) compared with untreated women. Presence of CUA might be associated with a detrimental effect on the probability of pregnancy achievement, spontaneous abortion and obstetric outcome. Hysteroscopic removal of a septum may reduce the probability of a spontaneous abortion. |
DOI | 10.1016/j.rbmo.2014.09.006 |
Alternate Journal | Reprod. Biomed. Online |
PubMed ID | 25444500 |