Cognitive event-related potentials: longitudinal changes in mild cognitive impairment.
Τίτλος | Cognitive event-related potentials: longitudinal changes in mild cognitive impairment. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Papaliagkas, V. T., Kimiskidis V. K., Tsolaki M. N., & Anogianakis G. |
Journal | Clin Neurophysiol |
Volume | 122 |
Issue | 7 |
Pagination | 1322-6 |
Date Published | 2011 Jul |
ISSN | 1872-8952 |
Λέξεις κλειδιά | Acoustic Stimulation, Aged, Alzheimer Disease, Cognition, Cognition Disorders, Disease Progression, Electroencephalography, Event-Related Potentials, P300, Evoked Potentials, Female, Humans, Intelligence Tests, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychometrics, Psychomotor Performance |
Abstract | OBJECTIVE: To measure changes over time in the latency and amplitude of the major waves of auditory event-related potentials (AERP) and their correlation with the memory status of patients with mild cognitive impairment (MCI).METHODS: AERPs were recorded in 22 MCI patients (mean±SD age=67.4±7.8, median (interquartile range-IQR) MMSE score=28 (27-29) in three consecutive exams and in 30 age-matched controls at baseline. During this time period, 3 patients converted to Alzheimer disease (AD). Latencies and amplitudes of N200, P300 and Slow Wave and the N200-P300 peak-to-peak amplitudes and latencies were determined, and correlation coefficients (CC) between them and MMSE scores were calculated.RESULTS: A significant increase in the P300 latency and a decrease in the N200 amplitude were observed between the exams. Only N200 latency correlated with baseline MMSE scores, whereas P300 and Slow Wave latencies correlated with age.CONCLUSIONS: N200 amplitude is more sensitive in identifying differences over time at the early stages of the disease, whereas P300 latency at later stages.SIGNIFICANCE: A new N2-P3 inter-peak index that incorporates changes in N200 and P300 latencies and amplitudes into a single parameter is introduced in order to adequately describe the gradual progress of MCI and its transition to AD. |
DOI | 10.1016/j.clinph.2010.12.036 |
Alternate Journal | Clin Neurophysiol |
PubMed ID | 21227748 |