Common breast cancer susceptibility loci are associated with triple-negative breast cancer.
Τίτλος | Common breast cancer susceptibility loci are associated with triple-negative breast cancer. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Stevens, K. N., Vachon C. M., Lee A. M., Slager S., Lesnick T., Olswold C., Fasching P. A., Miron P., Eccles D., Carpenter J. E., Godwin A. K., Ambrosone C., Winqvist R., Brauch H., Schmidt M. K., Cox A., Cross S. S., Sawyer E., Hartmann A., Beckmann M. W., Schulz-Wendtland R., Ekici A. B., Tapper W. J., Gerty S. M., Durcan L., Graham N., Hein R., Nickels S., Flesch-Janys D., Heinz J., Sinn H-P., Konstantopoulou I., Fostira F., Pectasides D., Dimopoulos A. M., Fountzilas G., Clarke C. L., Balleine R., Olson J. E., Fredericksen Z., Diasio R. B., Pathak H., Ross E., Weaver JE., Rüdiger T., Försti A., Dünnebier T., Ademuyiwa F., Kulkarni S., Pylkäs K., Jukkola-Vuorinen A., Ko Y-D., Van Limbergen E., Janssen H., Peto J., Fletcher O., Giles G. G., Baglietto L., Verhoef S., Tomlinson I., Kosma V-M., Beesley J., Greco D., Blomqvist C., Irwanto A., Liu J., Blows F. M., Dawson S-J., Margolin S., Mannermaa A., Martin N. G., Montgomery G. W., Lambrechts D., Silva I. Dos Santos, Severi G., Hamann U., Pharoah P., Easton D. F., Chang-Claude J., Yannoukakos D., Nevanlinna H., Wang X., & Couch F. J. |
Corporate Authors | GENICA consortium |
Journal | Cancer Res |
Volume | 71 |
Issue | 19 |
Pagination | 6240-9 |
Date Published | 2011 Oct 1 |
ISSN | 1538-7445 |
Λέξεις κλειδιά | Adult, Aged, Breast Neoplasms, Case-Control Studies, Chromosomes, Human, Pair 19, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Humans, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Estrogen, Receptors, Progesterone, Risk, Young Adult |
Abstract | Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. |
DOI | 10.1158/0008-5472.CAN-11-1266 |
Alternate Journal | Cancer Res. |
PubMed ID | 21844186 |
PubMed Central ID | PMC3327299 |
Grant List | 090532 / / Wellcome Trust / United Kingdom 10118 / / Cancer Research UK / United Kingdom 11022 / / Cancer Research UK / United Kingdom 5U01CA113916 / CA / NCI NIH HHS / United States A10119 / / Cancer Research UK / United Kingdom A10124 / / Cancer Research UK / United Kingdom C1287/A10118 / / Cancer Research UK / United Kingdom C1287/A5260 / / Cancer Research UK / United Kingdom C1287/A7497 / / Cancer Research UK / United Kingdom C490/A11021 / / Cancer Research UK / United Kingdom CA116201 / CA / NCI NIH HHS / United States CA122340 / CA / NCI NIH HHS / United States P-50CA83638 / CA / NCI NIH HHS / United States P30 CA016056 / CA / NCI NIH HHS / United States P30 CA016056-32 / CA / NCI NIH HHS / United States P30 CA016056-32 / CA / NCI NIH HHS / United States P50 CA083638 / CA / NCI NIH HHS / United States P50 CA083638-10 / CA / NCI NIH HHS / United States P50 CA089393 / CA / NCI NIH HHS / United States P50 CA089393 / CA / NCI NIH HHS / United States P50 CA089393-10 / CA / NCI NIH HHS / United States P50 CA116201 / CA / NCI NIH HHS / United States P50 CA116201-07 / CA / NCI NIH HHS / United States R01 CA122340 / CA / NCI NIH HHS / United States R01 CA122340-05 / CA / NCI NIH HHS / United States R25 CA092049 / CA / NCI NIH HHS / United States U01 CA069631 / CA / NCI NIH HHS / United States U01 CA069631-11 / CA / NCI NIH HHS / United States U01 CA113916 / CA / NCI NIH HHS / United States U01 CA113916-08 / CA / NCI NIH HHS / United States U01CA69631 / CA / NCI NIH HHS / United States |