Determination of prooxidant--antioxidant balance after acute coronary syndrome using a rapid assay: a pilot study.
| Τίτλος | Determination of prooxidant--antioxidant balance after acute coronary syndrome using a rapid assay: a pilot study. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Ghayour-Mobarhan, M., Alamdari D. Hamidi, Moohebati M., Sahebkar A., Nematy M., Safarian M., Azimi-Nezhad M., Parizadeh S. Mohammad R., Tavallaie S., Koliakos G., & Ferns G. |
| Journal | Angiology |
| Volume | 60 |
| Issue | 6 |
| Pagination | 657-62 |
| Date Published | 2009 Dec-2010 Jan |
| ISSN | 1940-1574 |
| Λέξεις κλειδιά | Acute Coronary Syndrome, Antioxidants, Biological Markers, Disease Progression, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Middle Aged, Oxidative Stress, Pilot Projects, Prognosis, Reactive Oxygen Species, Retrospective Studies, Risk Factors, Severity of Illness Index |
| Abstract | The purpose of the current study was to investigate a novel measure of oxidative stress in patients with acute coronary syndrome (ACS) using a pro-oxidant-antioxidant balance (PAB) assay, which is simple and rapid. Blood samples were taken from 94 patients admitted with ACS. Pro-oxidant-antioxidant balance values were determined in the first and second 12 hours after the onset of symptoms and compared with values for 81 age- and sex-matched controls. The mean PAB values in the first and second 12-hour samples of patients were both significantly higher than that of controls (P < .001). Among patients, PAB values were also significantly higher in the second samples compared with the first samples (P < .001). These findings indicate a heightened state of oxidative stress following ACS and suggest that the PAB value may be considered as a cardiovascular risk predictor to estimate the extent of oxidative stress. |
| DOI | 10.1177/0003319709333868 |
| Alternate Journal | Angiology |
| PubMed ID | 19398426 |
