The effect of chronically increased intra-abdominal pressure on rectus abdominis muscle histology an experimental study on rabbits.
Τίτλος | The effect of chronically increased intra-abdominal pressure on rectus abdominis muscle histology an experimental study on rabbits. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Kotidis, E. V., Papavramidis T. S., Ioannidis K., Cheva A., Lazou T., Michalopoulos N., Karkavelas G., & Papavramidis S. T. |
Journal | J Surg Res |
Volume | 171 |
Issue | 2 |
Pagination | 609-14 |
Date Published | 2011 Dec |
ISSN | 1095-8673 |
Λέξεις κλειδιά | Animals, Biopsy, Catheterization, Chronic Disease, Disease Models, Animal, Intra-Abdominal Hypertension, Male, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Obesity, Peritoneal Cavity, Pressure, Rabbits, Rectus Abdominis |
Abstract | BACKGROUND: The aim of this study was to specify the histologic response of the rectus abdominis muscle of the rabbit, to the chronically increased intra-abdominal pressure.MATERIALS AND METHODS: Forty-five New Zealand white rabbits were divided into three groups. In all groups, a rubber bag was implanted into the peritoneal cavity. In group A (n=15) the bags were kept empty. In group B (n=15) the bags were filled with normal saline in order to achieve an intra-abdominal pressure of over 12 mmHg. This pressure was kept at this level for 8 wk. In group C (n=15) the intra-abdominal rubber bags were filled with lead covered by silicone, equiponderant to the mean weight of the normal saline insufflated in group B. After 8 wk we took biopsies of the rectus abdominis muscle and counted the proportion of the different types of muscular fibers (type I, IIA, and IIB/X).RESULTS: Significant difference was found in the proportion of the three types of muscle fibers. Intra-abdominal hypertension led to an increase in type I fibers (P=0.008). No difference was noticed between groups A and C.CONCLUSIONS: The histologic response to the increased intra-abdominal pressure was an increase in type I muscle fibers. Charging with lead did not cause any significant change in the proportion of muscular fibers. |
DOI | 10.1016/j.jss.2010.06.034 |
Alternate Journal | J. Surg. Res. |
PubMed ID | 20850776 |