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Experimental investigation of the flow of a blood analogue fluid in a replica of a bifurcated small artery.

ΤίτλοςExperimental investigation of the flow of a blood analogue fluid in a replica of a bifurcated small artery.
Publication TypeJournal Article
Year of Publication2012
AuthorsAnastasiou, A. D., Spyrogianni A. S., Koskinas K. C., Giannoglou G. D., & Paras S. V.
JournalMed Eng Phys
Volume34
Issue2
Pagination211-8
Date Published2012 Mar
ISSN1873-4030
Λέξεις κλειδιάArteries, Biomimetic Materials, Blood Circulation, Humans, Pulsatile Flow, Stress, Mechanical
Abstract

The scope of this work is to study the pulsatile flow of a blood mimicking fluid in a micro channel that simulates a bifurcated small artery, in which the Fahraeus-Lindqvist effect is insignificant. An aqueous glycerol solution with small amounts of xanthan gum was used for simulating viscoelastic properties of blood and in vivo flow conditions were reproduced. Local flow velocities were measured using micro Particle Image Velocimetry (μ-PIV). From the measured velocity distributions, the wall shear stress (WSS) and its variation during a pulse were estimated. The Reynolds numbers employed are relatively low, i.e. similar to those prevailing during blood flow in small arteries. Experiments both with a Newtonian and a non-Newtonian fluid (having asymptotic viscosity equal to the viscosity of the Newtonian one) proved that the common assumption that blood behaves as a Newtonian fluid is not valid for blood flow in small arteries. It was also shown that the outer wall of the bifurcation, which is exposed to a lower WSS, is more predisposed to atherosclerotic plaque formation. Moreover, this region in small vessels is shorter than the one in large arteries, as the developed secondary flow decays faster. Finally, the WSS values in small arteries were found to be lower than those in large ones.

DOI10.1016/j.medengphy.2011.07.012
Alternate JournalMed Eng Phys
PubMed ID21824798

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