Fecal calprotectin measurement is a marker of short-term clinical outcome and presence of mucosal healing in patients with inflammatory bowel disease.
Τίτλος | Fecal calprotectin measurement is a marker of short-term clinical outcome and presence of mucosal healing in patients with inflammatory bowel disease. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Kostas, A., Siakavellas S. I., Kosmidis C., Takou A., Nikou J., Maropoulos G., Vlachogiannakos J., Papatheodoridis G. V., Papaconstantinou I., & Bamias G. |
Journal | World J Gastroenterol |
Volume | 23 |
Issue | 41 |
Pagination | 7387-7396 |
Date Published | 2017 Nov 07 |
ISSN | 2219-2840 |
Λέξεις κλειδιά | Adolescent, Adult, Aged, Biomarkers, Cohort Studies, Colitis, Ulcerative, Colonoscopy, Crohn Disease, Feces, Female, Follow-Up Studies, Humans, Intestinal Mucosa, Leukocyte L1 Antigen Complex, Male, Middle Aged, Prognosis, Recurrence, Remission Induction, Retrospective Studies, Severity of Illness Index, Young Adult |
Abstract | AIM: To evaluate the utility of fecal calprotectin (FC) in predicting relapse and endoscopic activity during follow-up in an inflammatory bowel disease (IBD) cohort.METHODS: All FC measurements that were obtained during a 3-year period from patients with inflammatory bowel disease in clinical remission were identified. Data regarding the short-term (6 mo) course of the disease were extracted from the medical files. Exclusion criteria were defined as: (1) An established flare of the disease at the time of FC measurement, (2) Loss to follow up within 6 mo from baseline FC measurement, and, (3) Insufficient data on file. Statistical analysis was performed to evaluate whether baseline FC measurement could predict the short term clinical relapse and/or the presence of mucosal healing.RESULTS: We included 149 [Crohn's disease (CD) = 113, Ulcerative colitis (UC) = 36, male = 77] IBD patients in our study. Within the determined 6-month period post-FC measurement, 47 (31.5%) had a disease flare. Among 76 patients who underwent endoscopy, 39 (51.3%) had mucosal healing. Baseline FC concentrations were significantly higher in those who had clinical relapse compared to those who remained in remission during follow up (481.0 μg/g, 286.0-600.0 89.0, 36.0-180.8, < 0.001). The significant predictive value of baseline median with IQR FC for clinical relapse was confirmed by multivariate Cox analysis [HR for 100μg/g: 1.75 (95%CI: 1.28-2.39), = 0.001]. Furthermore, lower FC baseline values significantly correlated to the presence of mucosal healing in endoscopy (69.0 μg/g, 30.0-128.0 481.0, 278.0-600.0, in those with mucosal inflammation, median with IQR, < 0.001). We were able to extract cut-off values for FC concentration with a high sensitivity and specificity for predicting clinical relapse (261 μg/g with AUC = 0.901, sensitivity 87.2%, specificity 85.3%, < 0.001) or mucosal healing (174 μg/g with AUC = 0.956, sensitivity 91.9%, specificity 87.2%, < 0.001). FC was better than CRP in predicting either outcome; nevertheless, having a pathological CRP (> 5 mg/L) in addition to the cut-offs for FC, significantly enhanced the specificity for predicting clinical relapse (95.1% from 85.3%) or endoscopic activity (100% from 87.2%).CONCLUSION: Serial FC measurements may be useful in monitoring IBD patients in remission, as FC appears to be a reliable predictor of short-term relapse and endoscopic activity. |
DOI | 10.3748/wjg.v23.i41.7387 |
Alternate Journal | World J. Gastroenterol. |
PubMed ID | 29151692 |
PubMed Central ID | PMC5685844 |