Statistical learning is a cognitive process of great importance for the detection and representation of environmental regularities. Complex cognitive processes such as statistical learning usually emerge as a result of the activation of widespread cortical areas functioning in dynamic networks. The present study investigated the cortical large-scale network supporting statistical learning of tone sequences in humans. The reorganization of this network related to musical expertise was assessed via a cross-sectional comparison of a group of musicians to a group of non-musicians. The cortical responses to a statistical learning paradigm incorporating an oddball approach were measured via Magnetoencephalographic (MEG) recordings. Large-scale connectivity of the cortical activity was calculated via a statistical comparison of the estimated transfer entropy in the sources' activity. Results revealed the functional architecture of the network supporting the processing of statistical learning, highlighting the prominent role of informational processing pathways that bilaterally connect superior temporal and intraparietal sources with the left IFG. Musical expertise is related to extensive reorganization of this network, as the group of musicians showed a network comprising of more widespread and distributed cortical areas as well as enhanced global efficiency and increased contribution of additional temporal and frontal sources in the information processing pathway.