Histologic evaluation of femoral nerve demyelinating and axonal neuropathy in Wistar rats due to alendronate intake: a randomised study.
Τίτλος | Histologic evaluation of femoral nerve demyelinating and axonal neuropathy in Wistar rats due to alendronate intake: a randomised study. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Theodora, P., Apostolos P., Vasileios P., Sofia K., Eva-Maria D., & Antonia S. |
Journal | J Biol Res (Thessalon) |
Volume | 27 |
Pagination | 2 |
Date Published | 2020 Dec |
ISSN | 1790-045X |
Abstract | Background: Bisphosphonates (BPs) are forceful inhibitors of osteoclast-mediated bone resorption. Long-term BP use is associated with multiple rare but severe adverse effects. The objective of this study was to investigate the possible effects of BPs in the structure of femoral nerve. Specimens from the femoral nerve of ten female 12-month old Wistar rats were used as control group and ten female 12-month old Wistar rats to which Alendronate (Fosamax, Merck) was administered per os for 13 weeks, were used as research group. Samples were observed under a Transmission Electron Microscope. G ratio measurements and statistical analysis with SPSS program were also performed. |
DOI | 10.1186/s40709-020-0112-z |
Alternate Journal | J Biol Res (Thessalon) |
PubMed ID | 32099834 |
PubMed Central ID | PMC7029514 |