Hypovitaminosis D and peripheral arterial disease: emerging link beyond cardiovascular risk factors.
Τίτλος | Hypovitaminosis D and peripheral arterial disease: emerging link beyond cardiovascular risk factors. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Gouveri, E., Papanas N., Hatzitolios A. I., & Maltezos E. |
Journal | Eur J Intern Med |
Volume | 23 |
Issue | 8 |
Pagination | 674-81 |
Date Published | 2012 Dec |
ISSN | 1879-0828 |
Λέξεις κλειδιά | Animals, Atherosclerosis, Humans, Peripheral Arterial Disease, Prevalence, Risk Factors, Vitamin D Deficiency |
Abstract | Vitamin D has received increasing interest for its beneficial effect on health. Beyond its conventional role in bone metabolism, emerging evidence suggests a possible link between low vitamin D levels and cardiovascular disease (CVD), including peripheral arterial disease (PAD), and cardiovascular risk factors. Vitamin D interacts either directly with the vascular tree or indirectly through its association with cardiovascular risk factors, but the exact mechanism remains controversial. This review outlines the association between hypovitaminosis D and PAD. Both entities are quite prevalent in the general population and, therefore, their potential association might have important clinical implications. Whether vitamin D deficiency represents a novel risk factor for PAD/CVD, and whether vitamin D supplementation would reduce the burden of CVD still remains to be answered. Until then, vitamin D intake is not recommended for PAD/CVD prevention. Outdoor physical activity, coupled with adequate but safe sun exposure, is a healthy lifestyle practice suggested for the prevention of both PAD and hypovitaminosis D. |
DOI | 10.1016/j.ejim.2012.07.001 |
Alternate Journal | Eur. J. Intern. Med. |
PubMed ID | 22835416 |