Immunoglobulin deficiencies: the B-lymphocyte side of DiGeorge Syndrome.
| Τίτλος | Immunoglobulin deficiencies: the B-lymphocyte side of DiGeorge Syndrome. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Patel, K., Akhter J., Kobrynski L., Gathmann M. A. Benjamin, Gathman B., Davis O., & Sullivan K. E. |
| Corporate Authors | International DiGeorge Syndrome Immunodeficiency Consortium |
| Journal | J Pediatr |
| Volume | 161 |
| Issue | 5 |
| Pagination | 950-3 |
| Date Published | 2012 Nov |
| ISSN | 1097-6833 |
| Λέξεις κλειδιά | Adolescent, Adult, B-Lymphocytes, Child, Child, Preschool, Cohort Studies, DiGeorge Syndrome, Europe, Humans, IgA Deficiency, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunoglobulins, Infant, Infant, Newborn, Middle Aged, Prevalence, Registries, T-Lymphocytes, United States |
| Abstract | DiGeorge syndrome is associated with a T-lymphocyte immunodeficiency. The prevalence of hypogammaglobulinemia has not been reported. We found that 3% of patients with DiGeorge syndrome were receiving immunoglobulin replacement therapy and 6% of patients over the age of 3 years had hypogammaglobulinemia. We conclude that DiGeorge syndrome is associated with significant humoral immune deficiency. |
| DOI | 10.1016/j.jpeds.2012.06.018 |
| Alternate Journal | J Pediatr |
| PubMed ID | 22809661 |
