Loeffler endocarditis in a pediatric patient.
Τίτλος | Loeffler endocarditis in a pediatric patient. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Keivanidou, A., Giannopoulos A., Papageorgiou T., Hatzipantelis E., Pana Z., & Athanasiadou F. |
Journal | Pediatr Hematol Oncol |
Volume | 31 |
Issue | 4 |
Pagination | 375-9 |
Date Published | 2014 May |
ISSN | 1521-0669 |
Λέξεις κλειδιά | Antineoplastic Agents, Benzamides, Child, Preschool, Electrocardiography, Female, Humans, Hypereosinophilic Syndrome, Imatinib Mesylate, Piperazines, Pyrimidines |
Abstract | Loefler endocarditis is a potential fatal adverse event of hypereosinophilic syndrome. We report a case of a 5-year-old girl diagnosed with peripheral hypereosinophilia refractory to corticosteroid therapy who developed eosinophilia-related endocarditis. Echocardiography revealed infiltration of the left ventricular free wall and the posterior mitral leaflet causing moderate mitral regurgitation. Genetic tests failed to recognize FIPiLi-PDGRFA genotype; however imatinib, a tyrosine kinase inhibitor was initiated. After a 4-week period of treatment there was a complete resolution of eosinophilia and a complete recovery of cardiac manifestation. This case highlights the introduction of imatinib for the treatment of hypereosinophilic syndrome refractory to corticosteroid therapy even in the absence of FIPiLi-PDGRFA genotype in pediatric patients. |
DOI | 10.3109/08880018.2013.806619 |
Alternate Journal | Pediatr Hematol Oncol |
PubMed ID | 23802753 |