Low-risk papillary thyroid carcinoma patients who underwent near-total thyroidectomy without prophylactic central compartment lymph node dissection and were ablated with low-dose 50mCi RAI had excellent 10-year prognosis.
Τίτλος | Low-risk papillary thyroid carcinoma patients who underwent near-total thyroidectomy without prophylactic central compartment lymph node dissection and were ablated with low-dose 50mCi RAI had excellent 10-year prognosis. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Michalaki, M., Bountouris P., Roupas N. D., Theodoropoulou A., Agalianou N., Alexandrides T., & Markou K. |
Journal | Hormones (Athens) |
Volume | 15 |
Issue | 4 |
Pagination | 511-517 |
Date Published | 2016 Oct |
ISSN | 2520-8721 |
Λέξεις κλειδιά | Adult, Carcinoma, Carcinoma, Papillary, Female, Humans, Male, Middle Aged, Neoplasm Grading, Outcome Assessment (Health Care), Prognosis, Radiotherapy, Retrospective Studies, Thyroid Neoplasms, Thyroidectomy |
Abstract | BACKGROUND: The current trend in the management of low risk differentiated thyroid carcinoma is to follow less aggressive strategies.OBJECTIVE: To assess the long-term morbidity and mortality outcomes of low-risk papillary thyroid carcinoma (PTC) patients undergoing minimal intervention.DESIGN: We retrospectively analyzed 137 patients with low-risk PTC (stage I: n=77; stage II: n=60). Of these patients, 107 (Group 1) had macro-PTC and underwent near-total thyroidectomy and received postoperatively 50mCi RAI. The remaining 30 patients (Group 2) had micro-PTC (<1cm) and were treated only by means of near-total thyroidectomy.RESULTS: The median follow-up for Group 1 patients was 10 years (range: 3-30). At 1-year evaluation, 8 patients of Group 1 had indeterminate or incomplete biochemical response, of whom 4 had also incomplete structural response to initial therapy. Only 1 of 4 patients with structural incomplete response underwent cervical lymph node dissection and then received an additional dose of 100mCi RAI. The remaining 7 patients received only an additional dose of 100mCi RAI. These patients have been continuously followed till the present time with no recurrences or deaths (median follow-up: 17.5 years; 3-30 years). At 15 years, 2 patients of Group 1 experienced biochemical recurrence and they received 100mCi RAI. Three patients of Group 2 experienced recurrence, with 2 receiving 50mCi RAI and 1 undergoing cervical lymph node dissection with 50mCi RAI.CONCLUSIONS: Patients with low-risk macro-PTC treated by means of near-total thyroidectomy without PCCLND and receiving postoperatively a low dose of 50mCi RAI have excellent long-term prognosis. |
DOI | 10.14310/horm.2002.1694 |
Alternate Journal | Hormones (Athens) |
PubMed ID | 28222412 |