Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study.
Τίτλος | Memory Correlates of Alzheimer's Disease Cerebrospinal Fluid Markers: A Longitudinal Cohort Study. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Reijs, B. L. R., Ramakers I. H. G. B., Köhler S., Teunissen C. E., Koel-Simmelink M., Nathan P. J., Tsolaki M., Wahlund L-O., Waldemar G., Hausner L., Vandenberghe R., Johannsen P., Blackwell A., Vanderstichele H., Verhey F., & Visser P. Jelle |
Journal | J Alzheimers Dis |
Volume | 60 |
Issue | 3 |
Pagination | 1119-1128 |
Date Published | 2017 |
ISSN | 1875-8908 |
Λέξεις κλειδιά | Aged, Alzheimer Disease, Amyloid beta-Peptides, Apolipoproteins E, Biomarkers, Cognitive Dysfunction, Disease Progression, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Memory, Middle Aged, Neuropsychological Tests, Peptide Fragments, tau Proteins |
Abstract | BACKGROUND: Performance on episodic, semantic, and working memory tests is impaired in Alzheimer's disease (AD)-type dementia, but it is unclear which type of memory test is most strongly associated with early AD biomarkers in cerebrospinal fluid (CSF), and most useful for monitoring disease progression.OBJECTIVE: To examine the association between amyloid-β 1-42 (Aβ42) and tau in CSF with performance on different memory domains at baseline, and how these CSF markers are related with memory decline.METHODS: We included 263 individuals with normal cognition, mild cognitive impairment, AD-type dementia, and non-AD dementia from the European EDAR study. Assessment included CSF Aβ42 and t-tau analyses with INNO-BIA AlzBio3 Luminex assay, the CERAD wordlist learning and delayed recall, animal fluency test, and the CANTAB Paired Associates Learning (PAL) and Spatial Working Memory tasks. Follow-up assessments were performed within 3 years after baseline.RESULTS: At baseline, decreased CSF Aβ42 correlated most strongly with the PAL total errors adjusted and the wordlist delayed recall and increased CSF t-tau with the wordlist delayed recall. Over time, decreased CSF Aβ42 was associated with decline on the wordlist learning, whereas increased CSF t-tau were associated with decline in scores on the wordlist learning, wordlist delayed recall, and animal fluency. Associations were independent of baseline diagnosis.CONCLUSION: Tests assessing episodic verbal and visuospatial memory are most useful for detection of AD pathology. Tests for episodic verbal memory and semantic memory are most useful for tracking memory decline. |
DOI | 10.3233/JAD-160766 |
Alternate Journal | J. Alzheimers Dis. |
PubMed ID | 28984585 |