Oral calcium supplementation ambulatory blood pressure and relation to changes in intracellular ions and sodium-hydrogen exchange.
Τίτλος | Oral calcium supplementation ambulatory blood pressure and relation to changes in intracellular ions and sodium-hydrogen exchange. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Pikilidou, M. I., Befani C. D., Sarafidis P. A., Nilsson P. M., Koliakos G. G., Tziolas I. M., Kazakos K. A., Yovos J. G., & Lasaridis A. N. |
Journal | Am J Hypertens |
Volume | 22 |
Issue | 12 |
Pagination | 1263-9 |
Date Published | 2009 Dec |
ISSN | 1941-7225 |
Λέξεις κλειδιά | Aged, Blood Pressure, Calcium, Calcium, Dietary, Diabetes Mellitus, Type 2, Dietary Supplements, Female, Humans, Hypertension, Magnesium, Male, Middle Aged, Potassium, Single-Blind Method, Sodium, Sodium-Hydrogen Antiporter |
Abstract | BACKGROUND: Calcium (Ca2+) supplementation has been shown paradoxically to reduce intracellular Ca2+ and induce vascular relaxation. The aim of the study was to assess 24-h blood pressure (BP) change after Ca2+ supplementation and to investigate its relation to changes in intracellular ions and the activity of the first isoform of sodium-hydrogen exchange (NHE-1) in subjects with hypertension and type 2 diabetes.METHODS: This parallel, randomized controlled, single-blinded trial, consisted of 31 patients with type 2 diabetes, and hypertension who were allocated to receive 1,500 mg of Ca2+ per day (n = 15) or no treatment (n = 16) for 8 weeks.RESULTS: In the Ca2+ group a decrease of 1.7 +/- 2.7 mm Hg (mean +/- SE) P = 0.52 for mean 24-h systolic BP (SBP) and 2.1 +/- 1.5 mm Hg, P = 0.19 for mean 24-h diastolic BP (DBP) was recorded. Whereas in the control group an increase of 1.4 +/- 2.7 mm Hg, P = 0.59 for mean 24-h SBP and 1.2 +/- 2.8 mm Hg, P = 0.83 for mean 24-h DBP was observed. Intraplatelet Ca2+ decreased whereas intraplatelet magnesium (Mg2+) and erythrocyte K+ increased in the intervention group. Change in mean 24-h SBP in the pooled group correlated with both change in intraplatelet Ca2+ (r = 0.49, P < 0.05) and NHE-1 activity (r = 0.6, P < 0.001). The contribution of intraplatelet Ca2+ was attenuated when both parameters were entered in a multivariate regression model.CONCLUSIONS: The present study shows a weak, statistically nonsignificant trend towards association of Ca2+ supplementation on 24-h BP in hypertensive subjects with type 2 diabetes. However, our results indicated an interrelation of [Ca2+]i levels and NHE-1 activity on BP in patients with hypertension and type 2 diabetes. |
DOI | 10.1038/ajh.2009.182 |
Alternate Journal | Am. J. Hypertens. |
PubMed ID | 19779467 |