Oral ulcers in patients with advanced breast cancer receiving everolimus: a case series report on clinical presentation and management.
| Τίτλος | Oral ulcers in patients with advanced breast cancer receiving everolimus: a case series report on clinical presentation and management. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Nicolatou-Galitis, O., Nikolaidi A., Athanassiadis I., Papadopoulou E., & Sonis S. |
| Journal | Oral Surg Oral Med Oral Pathol Oral Radiol |
| Volume | 116 |
| Issue | 2 |
| Pagination | e110-6 |
| Date Published | 2013 Aug |
| ISSN | 2212-4411 |
| Λέξεις κλειδιά | Aged, Androstadienes, Anti-Inflammatory Agents, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Carcinoma, Dexamethasone, Everolimus, Female, Follow-Up Studies, Glucocorticoids, Humans, Middle Aged, Oral Ulcer, Prospective Studies, Recurrence, Sirolimus, Stomatitis, Stomatitis, Aphthous, TOR Serine-Threonine Kinases, Treatment Outcome |
| Abstract | OBJECTIVE: We report the clinical features and management outcomes in 7 patients with everolimus-related stomatitis.STUDY DESIGN: Fifteen women with hormone-receptor-positive advanced breast cancer receiving everolimus combined with exemestane were prospectively evaluated to assess the development of stomatitis. Oral ulcers were diagnosed based on established criteria.RESULTS: Seven patients developed stomatitis (46.6%). All patients were treated with topical dexamethasone solution, while everolimus was temporarily discontinued in 4 patients. Stomatitis resolved within 1-2 weeks. Two of the 4 patients, who had interrupted everolimus, developed recurrent stomatitis following drug resume and everolimus was again discontinued and restarted after 2 weeks. To date, 5 patients receive everolimus in full dose. The 2 patients, who developed recurrent stomatitis, received a reduced dose.CONCLUSIONS: Everolimus-related oral ulcers were frequent and led to dose modifications. Controlled trials, endorsing a consensus in terminology, are needed to evaluate measures on prevention and management of this unique toxicity. |
| DOI | 10.1016/j.oooo.2013.02.022 |
| Alternate Journal | Oral Surg Oral Med Oral Pathol Oral Radiol |
| PubMed ID | 23643584 |
