Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture.
Τίτλος | Parecoxib has non-significant long-term effects on bone healing in rats when administered for a short period after fracture. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Akritopoulos, P., Papaioannidou P., Hatzokos I., Haritanti A., Iosifidou E., Kotoula M., & Mirtsou-Fidani V. |
Journal | Arch Orthop Trauma Surg |
Volume | 129 |
Issue | 10 |
Pagination | 1427-32 |
Date Published | 2009 Oct |
ISSN | 1434-3916 |
Λέξεις κλειδιά | Animals, Cyclooxygenase Inhibitors, Femoral Fractures, Fracture Fixation, Intramedullary, Fracture Healing, Isoxazoles, Male, Rats, Rats, Wistar |
Abstract | INTRODUCTION: Selective and non-selective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of parecoxib, a selective COX-2 inhibitor, on bone healing in rats, when it is applied in a pattern similar to clinical treatment patterns, that is, in a high dose and for a short period after bone fracture.METHOD: Closed non-displaced mid-diaphyseal fractures in the middle of the left femoral shaft were generated in each animal. In the study group, parecoxib sodium (1.06 mg/kg) was administered intra-peritoneally every day for 7 days. In the control group, normal saline was administered intra-peritoneally every day for 7 days. In both groups fracture healing (bone union and callus formation) was evaluated with X-rays 28 and 42 days after surgery.RESULTS: Bone healing was lower in the study group (60 vs. 80% in the control group 28 days after fracture and 80 vs. 90% 42 days after fracture) but this difference was not statistically significant (P > 0.05).CONCLUSION: Parecoxib does not have a significant long-term effect on bone healing in rats, when it is administered in a high dose and for a short period after bone fracture. |
DOI | 10.1007/s00402-008-0707-6 |
Alternate Journal | Arch Orthop Trauma Surg |
PubMed ID | 18677494 |
PubMed Central ID | PMC2729985 |