Compliance with antihypertensive therapy decreases over time and as the number of pills increases. This case describes a 64-year-old male with hypertension who was initially prescribed antihypertensive therapy with olmesartan (OLM) once daily in the morning and amlodipine (AML) once daily in the evening. Reductions in blood pressure (BP) were observed, but BP control was not achieved. Therefore, an evening dose of hydrochlorothiazide (HCTZ) was added to the treatment regimen. Despite stating that he was adhering to therapy, the patient's prescription records indicated otherwise. The patient was switched to an OLM/AML/HCTZ single-pill fixed-dose combination and BP had decreased to the normal range at a follow-up visit 3 months later.