Peak intraocular pressure and glaucomatous progression in primary open-angle glaucoma.
Τίτλος | Peak intraocular pressure and glaucomatous progression in primary open-angle glaucoma. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Konstas, A. G. P., Quaranta L., Mikropoulos D. G., Nasr M. B., Russo A., Jaffee H. A., Stewart J. A., & Stewart W. C. |
Journal | J Ocul Pharmacol Ther |
Volume | 28 |
Issue | 1 |
Pagination | 26-32 |
Date Published | 2012 Feb |
ISSN | 1557-7732 |
Λέξεις κλειδιά | Aged, Disease Progression, Female, Follow-Up Studies, Glaucoma, Open-Angle, Humans, Intraocular Pressure, Male, Middle Aged, Multivariate Analysis, Regression Analysis, Retrospective Studies, Risk Factors, Time Factors |
Abstract | PURPOSE: To evaluate the effect of 24-h peak intraocular pressure (IOP) on the progression of primary open-angle glaucoma (POAG) and the 24 h time points that best predict peak pressure.METHODS: A retrospective analysis of clinical data evaluating long-term glaucomatous progression in patients with POAG who were previously in a 24-h study of the authors (IOP readings at 2/6/10 A.M. and 2/6/10 PM); had ≥3 treated 10 A.M. (±1 h) IOP measurements over 5-years after an untreated 24-h baseline; and had a treated 24-h curve with a 10 A.M. IOP±2 mmHg within the 10 A.M. mean IOP over 5-years.RESULTS: We included 98 nonprogressed and 53 progressed patients with POAG (n=151). The mean 24-h peak IOP (mmHg) was 19.9±2.7 for progressed and 18.3±2.0 for nonprogressed patients (P<0.001). Progressed patients also showed a higher mean 24-h IOP. Generally, patients with a mean or peak daytime (readings at 10 A.M., 2 and 6 P.M.) or 24-h peak IOP of ≤18 remained nonprogressed in 75%-78% of cases. Further, measuring IOP at night found a higher peak in only 20% of cases, which was ≤2 of the daytime peak in 98% of cases. A multivariate regression analysis showed only 24-h peak IOP as an independent risk factor for progression (P=0.002).CONCLUSIONS: This study suggests that daytime peak IOP may be clinically important in predicting long-term glaucomatous progression. Further, daytime peak IOP may assist, as much as daytime mean IOP and, in most cases, 24-h peak IOP, in helping to guide long-term treatment in POAG. |
DOI | 10.1089/jop.2011.0081 |
Alternate Journal | J Ocul Pharmacol Ther |
PubMed ID | 22004074 |