Perioperative Use of Erythromycin Reduces Cognitive Decline After Coronary Artery Bypass Grafting Surgery: A Pilot Study.
Τίτλος | Perioperative Use of Erythromycin Reduces Cognitive Decline After Coronary Artery Bypass Grafting Surgery: A Pilot Study. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Thomaidou, E., Argiriadou H., Vretzakis G., Megari K., Taskos N., Chatzigeorgiou G., & Anastasiadis K. |
Journal | Clin Neuropharmacol |
Volume | 40 |
Issue | 5 |
Pagination | 195-200 |
Date Published | 2017 Sep/Oct |
ISSN | 1537-162X |
Λέξεις κλειδιά | Aged, Biomarkers, Cognitive Dysfunction, Coronary Artery Bypass, Erythromycin, Female, Humans, Interleukin-1, Interleukin-6, Male, Middle Aged, Neuroprotective Agents, Neuropsychological Tests, Perioperative Care, Pilot Projects, Postoperative Complications, tau Proteins |
Abstract | OBJECTIVES: Adverse neurologic outcome can be a debilitating complication after cardiac surgery. The aim of this study was to investigate the potential neuroprotective action of erythromycin, a well known antibiotic agent, regarding postoperative cognitive decline in patients undergoing cardiac surgery.METHODS: Forty patients scheduled for elective coronary artery bypass grafting surgery were prospectively randomly assigned in 2 groups: the erythromycin group (n = 19) who received erythromycin at a dose of 25 mg/kg before and after surgery and the control group (n = 21) who did not receive it. All patients were monitored with near-infrared spectroscopy during the operation. Interleukin (IL) 1 and IL-6 as inflammatory markers and tau protein as a marker of brain injury were measured before and after surgery. Neurocognitive assessment was performed before surgery, on the day of discharge, and at 3 months postoperatively.RESULTS: Both groups were comparable in terms of demographic and clinical data. Patients who took erythromycin presented with significantly better cognitive performance before discharge and 3 months after surgery. No significant differences between the 2 groups referring to IL-1 and IL-6 values were detected. Tau serum values were lower in the erythromycin group after surgery.CONCLUSIONS: Erythromycin administration attenuates cerebral damage and postoperative cognitive decline after coronary artery bypass grafting surgery.TRIAL REGISTRATION: The study was retrospectively registered at ClinicalTrials.gov (NCT01274754). Study start day: November 2008. |
DOI | 10.1097/WNF.0000000000000238 |
Alternate Journal | Clin Neuropharmacol |
PubMed ID | 28816833 |