Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.
Τίτλος | Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Ohmasa, F., Saito M., Oiwa H., Tsounapi P., Shomori K., Kitatani K., Dimitriadis F., Kinoshita Y., & Satoh K. |
Journal | BJU Int |
Volume | 110 |
Issue | 6 Pt B |
Pagination | E245-52 |
Date Published | 2012 Sep |
ISSN | 1464-410X |
Λέξεις κλειδιά | Animals, Cromakalim, Glyburide, KATP Channels, Male, Nicorandil, Rats, Rats, Sprague-Dawley, Urinary Retention |
Abstract | UNLABELLED: What's known on the subject? and What does the study add? Acute urinary retention (AUR) and catheterization for AUR (AURC) or drainage of the urine is a well established cause of bladder dysfunction. Previously, we reported that the induction of AURC significantly reduced contractile responses to both carbachol and KCl compared with a control group, and that this reduction was prevented by nicorandil and cromakalim in a dose-dependent manner; however, although we reported a possible beneficial effect of nicorandil and cromakalim on bladder dysfunction caused by AURC, its molecular mechanism is still unknown. Our study establishes that nicorandil and cromakalim, but not glibenclamide, prevent AURC-induced bladder dysfunction via up-regulation of both K(IR)6.1 and K(IR)6.2 with a subsequent decrease in oxidative stress and decreased induction of apoptosis in the bladder. |
DOI | 10.1111/j.1464-410X.2012.10965.x |
Alternate Journal | BJU Int |
PubMed ID | 22369430 |