Plasmablasts During Acute Dengue Infection Represent a Small Subset of a Broader Virus-specific Memory B Cell Pool.
Τίτλος | Plasmablasts During Acute Dengue Infection Represent a Small Subset of a Broader Virus-specific Memory B Cell Pool. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Appanna, R., Kg S., Xu M. Hui, Toh Y-X., Velumani S., Carbajo D., Lee C. Yin, Zuest R., Balakrishnan T., Xu W., Lee B., Poidinger M., Zolezzi F., Leo Y. Sin, Thein T. Linn, Wang C-I., & Fink K. |
Journal | EBioMedicine |
Volume | 12 |
Pagination | 178-188 |
Date Published | 2016 Oct |
ISSN | 2352-3964 |
Λέξεις κλειδιά | Acute Disease, Animals, Antibodies, Viral, Antibody Specificity, Antigens, Viral, B-Lymphocyte Subsets, Cell Line, Clonal Evolution, Cross Reactions, Dengue, Dengue Virus, Humans, Immunoglobulin G, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Immunologic Memory, Immunophenotyping, Neutralization Tests, Phenotype, Plasma Cells |
Abstract | Dengue is endemic in tropical countries worldwide and the four dengue virus serotypes often co-circulate. Infection with one serotype results in high titers of cross-reactive antibodies produced by plasmablasts, protecting temporarily against all serotypes, but impairing protective immunity in subsequent infections. To understand the development of these plasmablasts, we analyzed virus-specific B cell properties in patients during acute disease and at convalescence. Plasmablasts were unrelated to classical memory cells expanding in the blood during early recovery. We propose that only a small subset of memory B cells is activated as plasmablasts during repeat infection and that plasmablast responses are not representative of the memory B cell repertoire after dengue infection. |
DOI | 10.1016/j.ebiom.2016.09.003 |
Alternate Journal | EBioMedicine |
PubMed ID | 27628668 |
PubMed Central ID | PMC5078588 |