Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers.
| Τίτλος | Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Handels, R. L. H., Vos S. J. B., Kramberger M. G., Jelic V., Blennow K., van Buchem M., van der Flier W., Freund-Levi Y., Hampel H., Rikkert M. Olde, Oleksik A., Pirtosek Z., Scheltens P., Soininen H., Teunissen C., Tsolaki M., Wallin A. K., Winblad B., Verhey F. R. J., & Visser P. Jelle |
| Journal | Alzheimers Dement |
| Volume | 13 |
| Issue | 8 |
| Pagination | 903-912 |
| Date Published | 2017 Aug |
| ISSN | 1552-5279 |
| Λέξεις κλειδιά | Aged, Aged, 80 and over, Biomarkers, Cognitive Dysfunction, Dementia, Disease Progression, Educational Status, Female, Follow-Up Studies, Humans, Logistic Models, Magnetic Resonance Imaging, Male, Mental Status and Dementia Tests, Middle Aged, Prognosis, Risk Assessment, Temporal Lobe |
| Abstract | INTRODUCTION: We aimed to determine the added value of cerebrospinal fluid (CSF) to clinical and imaging tests to predict progression from mild cognitive impairment (MCI) to any type of dementia.METHODS: The risk of progression to dementia was estimated using two logistic regression models based on 250 MCI participants: the first included standard clinical measures (demographic, clinical, and imaging test information) without CSF biomarkers, and the second included standard clinical measures with CSF biomarkers.RESULTS: Adding CSF improved predictive accuracy with 0.11 (scale from 0-1). Of all participants, 136 (54%) had a change in risk score of 0.10 or higher (which was considered clinically relevant), of whom in 101, it was in agreement with their dementia status at follow-up.DISCUSSION: An individual person's risk of progression from MCI to dementia can be improved by relying on CSF biomarkers in addition to recommended clinical and imaging tests for usual care. |
| DOI | 10.1016/j.jalz.2016.12.015 |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 28216393 |
