PTTG-1 (Securin) immunoexpression in meningiomas correlates with tumor grade and proliferation rate: potential use as a diagnostic marker of malignancy.
Τίτλος | PTTG-1 (Securin) immunoexpression in meningiomas correlates with tumor grade and proliferation rate: potential use as a diagnostic marker of malignancy. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Iliadis, A., Virvili M-A., Flaris N. A., Pervana S., Pazarli E., Tripsianis G., Grigoriou M. E., Efstratiou I., & Kanakis D. N. |
Journal | APMIS |
Volume | 126 |
Issue | 4 |
Pagination | 295-302 |
Date Published | 2018 Apr |
ISSN | 1600-0463 |
Λέξεις κλειδιά | Biomarkers, Tumor, Cell Proliferation, Gene Expression Regulation, Neoplastic, Humans, Ki-67 Antigen, Meningeal Neoplasms, Meningioma, Mitosis, Securin |
Abstract | This study essentially aims to contribute to the immunohistochemical investigation of the use of pituitary tumor transforming gene (PTTG) as a marker of cell proliferation or advanced tumor grade in meningiomas of various WHO grades. In all, 51 cases were recovered in total, 21 Grade-I, 23 Grade-II and 7 Grade-III meningiomas. Mitotic index (MI), Ki-67/MiB-1 positivity percentage and PTTG expression were analyzed in correlation to each other as well as to the tumor WHO grades. All three biomarkers showed a high diagnostic significance and a strong association with WHO grades. In comparison, PTTG expression was on a par with the other two indices, and performed very well regarding identification of advanced grade tumors. PTTG may be considered an important diagnostic tool and serve in the future as a novel prognosticator of the biological behavior of all grade meningiomas as well as a useful high-risk patient selection tool. |
DOI | 10.1111/apm.12825 |
Alternate Journal | APMIS |
PubMed ID | 29575197 |