Restrictive pulmonary dysfunction and its predictors in young patients with β-thalassaemia major.
Τίτλος | Restrictive pulmonary dysfunction and its predictors in young patients with β-thalassaemia major. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Bourli, E., Dimitriadou M., Economou M., Vlachaki E., Christoforidis A., Maratou E., Stanopoulos I., Argyropoulou P., & Aivazis V. |
Journal | Pediatr Pulmonol |
Volume | 47 |
Issue | 8 |
Pagination | 801-7 |
Date Published | 2012 Aug |
ISSN | 1099-0496 |
Λέξεις κλειδιά | Adolescent, Adult, Age Factors, beta-Thalassemia, Child, Female, Ferritins, Humans, Lung Diseases, Male, Respiratory Function Tests, Risk Factors |
Abstract | BACKGROUND: Pulmonary dysfunction represents one of the most undervalued and less recognized complications in patients with β-thalassaemia.OBJECTIVES: The aim of this study was to assess the pattern of pulmonary dysfunction and consequently to investigate possible associated factors that might contribute to lung impairment in young patients with β-thalassaemia major.METHODS: Fifty-two children and young adults (mean age: 21.33 ± 6.24 years) with β-thalassaemia major on conventional treatment (transfusions and iron chelation therapy) were included in the study. A complete computerized pulmonary function testing (PFT) system for recording pulmonary diffusion capacity and simultaneous determination of alveolar volume and pulmonary volumes was equipped.RESULTS: Results showed that 20 patients (38.46%) had restrictive pulmonary pattern that was preferentially observed in older and shorter patients. Serum ferritin levels were higher in the restrictive group (2,096 ± 1,831 ng/dl) compared to patients with normal pulmonary function (1,354 ± 942 ng/dl) (P = 0.066). Diffusional impairment characterized by significantly lower DLCO*% values, was observed in the restrictive group (P = 0.004), implicating the 62.5% of the population studied. Paired linear correlations showed that age was negatively correlated to DLCO*% (r = -0.548, P < 0.001) and SaO(2) % (r = -0.789, P < 0.001) and with most of the pulmonary functional parameters that determine a restrictive. Multivariate regression analysis identified age as the major predictor for restrictive pulmonopathy followed by serum ferritin levels.CONCLUSIONS: Our study shows that pulmonary impairment is shown in a great proportion even among asymptomatic young thalassaemic patients, thus, regular screening of pulmonary function should be adopted in the routine clinical follow up of these patients. |
DOI | 10.1002/ppul.22506 |
Alternate Journal | Pediatr. Pulmonol. |
PubMed ID | 22328228 |