Twenty-four-hour intraocular pressure monitoring in normotensive patients undergoing chronic hemodialysis.
Τίτλος | Twenty-four-hour intraocular pressure monitoring in normotensive patients undergoing chronic hemodialysis. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Panagiotou, E. S., Liakopoulos V., Giannopoulos T., Voudouragkaki I. C., Demirtzi P., Paschalinou E., Nikitidou O., Kapis P. V., & Konstas A. G. P. |
Journal | Eur J Ophthalmol |
Volume | 26 |
Issue | 1 |
Pagination | 24-9 |
Date Published | 2016 Jan-Feb |
ISSN | 1724-6016 |
Λέξεις κλειδιά | Adult, Aged, Aged, 80 and over, Blood Pressure, Circadian Rhythm, Corneal Pachymetry, Female, Glaucoma, Open-Angle, Gonioscopy, Humans, Intraocular Pressure, Kidney Failure, Chronic, Male, Middle Aged, Monitoring, Physiologic, Prospective Studies, Renal Dialysis, Tonometry, Ocular |
Abstract | PURPOSE: To investigate 24-hour intraocular pressure (IOP) changes caused by hemodialysis (HD).METHODS: A prospective, observational, comparative 24-hour trial was performed on consecutive subjects with normal IOP undergoing maintenance HD 3 days a week between 13:00 and 17:00 hours in an academic setting. Following a comprehensive ocular assessment, those with conditions that may influence IOP were excluded and one eye was randomly selected. Twenty-four-hour IOP monitoring was performed on HD day 1 and then on a day without HD. The IOP was measured at 10:00, 13:00, 15:00, 17:00, 22:00, 02:00, and 06:00 employing Goldmann and Perkins tonometry on habitual position. During the course of 1 year, 18 patients completed the study.RESULTS: Monitoring of IOP on HD day showed a significantly higher mean 24-hour IOP (15.4 ± 2.7 vs 14.1 ± 2.2 mm Hg; p = 0.025), higher mean peak 24-hour IOP (18.5 ± 3.5 vs 15.8 ± 2.5 mm Hg; p = 0.003), and wider 24-hour IOP fluctuation (6.2 ± 2.3 vs 4.0 ± 1.9 mm Hg; p = 0.001). When individual time points were compared, IOP was significantly higher at 17:00 on HD day, reflecting a gradual IOP elevation during HD (p = 0.021). Further, during the HD procedure (13:00-17:00), the mean IOP was significantly higher on a HD day (16.4 ± 3.0 vs 14.7 ± 2.4 mm Hg; p = 0.004).CONCLUSIONS: This prospective, before/after trial suggests that HD significantly impacts 24-hour IOP characteristics in normotensive eyes. The long-term significance of these findings requires further elucidation in normotensive patients and, predominantly, in patients with glaucoma undergoing HD. |
DOI | 10.5301/ejo.5000651 |
Alternate Journal | Eur J Ophthalmol |
PubMed ID | 26165324 |