Urinary levels of epidermal growth factor, interleukin-6 and monocyte chemoattractant protein-1 may act as predictor markers of renal function outcome in immunoglobulin A nephropathy.
Τίτλος | Urinary levels of epidermal growth factor, interleukin-6 and monocyte chemoattractant protein-1 may act as predictor markers of renal function outcome in immunoglobulin A nephropathy. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Stangou, M., Alexopoulos E., Papagianni A., Pantzaki A., Bantis C., Dovas S., Economidou D., Leontsini M., & Memmos D. |
Journal | Nephrology (Carlton) |
Volume | 14 |
Issue | 6 |
Pagination | 613-20 |
Date Published | 2009 Sep |
ISSN | 1440-1797 |
Λέξεις κλειδιά | Adolescent, Adult, Aged, Biological Markers, Chemokine CCL2, Epidermal Growth Factor, Female, Glomerulonephritis, IGA, Humans, Interleukin-6, Kidney, Male, Middle Aged |
Abstract | AIM: Urinary cytokine excretion may reflect histological changes in immunoglobulin A nephropathy (IgAN), and their measurement can give information about disease outcome.METHODS: Thirty-three IgAN patients were prospectively followed for 5.6 +/- 3.1 years. Urinary levels of monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-6 and epidermal growth factor (EGF) were measured at diagnosis and repeated 1 year later for IL-6 and EGF.RESULTS: Urinary MCP-1 and IL-6 levels were increased significantly, while EGF excretion reduced in IgAN patients, compared to controls. IL-6 urinary levels showed significant positive correlation with chronic histological lesions. Patients were classified into five groups, according to the Haas classification system. MCP-1 and IL-6 urinary levels were increased, whereas EGF levels were reduced in the progression of staging. EGF urinary excretion was a strong predictor factor of disease outcome, significantly correlated with creatinine clearance at time of diagnosis (r = 0.5, P = 0.005), and at the end of follow up (r = 0.6, P = 0.001). Urinary EGF levels measured a year later could predict long-term outcome better, and a cut of 0.05 pg/mg urine creatinine levels could distinguish between progressors and non-progressors.CONCLUSION: Urinary MCP-1, IL-6 and EGF levels may represent histology in IgAN. EGF excretion can be a predictive marker and its serial measurements may give information about disease outcome and the effect of treatment. |
DOI | 10.1111/j.1440-1797.2008.01051.x |
Alternate Journal | Nephrology (Carlton) |
PubMed ID | 19143943 |