In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B.
Τίτλος | In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Kontogiannidou, E., Meikopoulos T., Gika H., Panteris E., Vizirianakis I. S., Müllertz A., & Fatouros D. G. |
Journal | Pharmaceutics |
Volume | 12 |
Issue | 8 |
Date Published | 2020 Jul 25 |
ISSN | 1999-4923 |
Abstract | Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB. |
DOI | 10.3390/pharmaceutics12080699 |
Alternate Journal | Pharmaceutics |
PubMed ID | 32722400 |
PubMed Central ID | PMC7463809 |
Grant List | Scholarship Code: 2093 / / Hellenic Foundation for Research and Innovation / |