Eradication of Infection Restores ki67, p53, and Cyclin D1 Immunoreactivity in the Human Gastric Epithelium.
Title | Eradication of Infection Restores ki67, p53, and Cyclin D1 Immunoreactivity in the Human Gastric Epithelium. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Triantafyllou, K., Papadopoulos V., Emanouil T., Gkolfakis P., Damaskou V., Tziatzios G., Panayiotides I. G., Vafiadis I., & Ladas S. D. |
Journal | Clin Med Insights Gastroenterol |
Volume | 9 |
Pagination | 73-78 |
Date Published | 2016 |
ISSN | 1179-5522 |
Abstract | INTRODUCTION: We evaluated the effect of (HP) eradication on p53, cyclin D1 expression, and cell proliferation in gastric mucosa.MATERIALS AND METHODS: We assessed p53, cyclin D1, and ki67 immunoexpression in gastric mucosa from 31 HP chronic gastritis patients and 12 controls. Reassessment was performed 6 months after successful HP eradication.RESULTS: Successful eradication resulted in significant decrease of p53 (1.53 ± 0.16 vs 0.83 ± 0.19, = 0.01) and ki67 (9.84 ± 0.96 vs 4.77 ± 0.27, < 0.001) staining in the antrum. Similarly, p53 immunoreactivity significantly decreased in the corpus (1.27 ± 0.20 vs 0.46 ± 0.15, = 0.02), while there was a trend for decreased corpus cyclin D1 and ki67 expression (0.17 ± 0.07 vs 0.0, = 0.08 and 8.71 ± 1.24 vs 5.85 ± 0.54, = 0.09, respectively). Importantly, after successful HP eradication, the immunoreactivity of the studied parameters was similar to that of controls.CONCLUSION: Successful HP infection eradication restores p53, cyclin D1, and ki67 immunoreactivity in the gastric mucosa to the level of controls. |
DOI | 10.4137/CGast.S38330 |
Alternate Journal | Clin Med Insights Gastroenterol |
PubMed ID | 27891056 |
PubMed Central ID | PMC5117488 |