Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for nor
| Title | Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for nor |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Melidou, A., & Broberg E. |
| Corporate Authors | European region influenza surveillance network |
| Journal | Vaccine |
| Volume | 35 |
| Issue | 37 |
| Pagination | 4828-4835 |
| Date Published | 2017 09 05 |
| ISSN | 1873-2518 |
| Keywords | Europe, Humans, Influenza A Virus, H3N2 Subtype, Influenza Vaccines, Influenza, Human, Lectins, World Health Organization |
| Abstract | During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses. |
| DOI | 10.1016/j.vaccine.2017.07.057 |
| Alternate Journal | Vaccine |
| PubMed ID | 28780977 |
