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Liver Transplantation in the Obese Cirrhotic Patient.

TitleLiver Transplantation in the Obese Cirrhotic Patient.
Publication TypeJournal Article
Year of Publication2017
AuthorsSpengler, E. K., O'Leary J. G., Te H. S., Rogal S., Pillai A. A., Al-Osaimi A., Desai A., Fleming J. N., Ganger D., Seetharam A., Tsoulfas G., Montenovo M., & Lai J. C.
JournalTransplantation
Volume101
Issue10
Pagination2288-2296
Date Published2017 10
ISSN1534-6080
KeywordsAdiposity, Bariatric Surgery, Body Mass Index, Comorbidity, End Stage Liver Disease, Graft Survival, Health Status, Humans, Liver Cirrhosis, Liver Transplantation, Obesity, Postoperative Complications, Risk Assessment, Risk Factors, Risk Reduction Behavior, Time Factors, Treatment Outcome, Waiting Lists, Weight Loss
Abstract

Despite the rapidly increasing prevalence of obesity in the transplant population, the optimal management of obese liver transplant candidates remains undefined. Setting strict body mass index cutoffs for transplant candidacy remains controversial, with limited data to guide this practice. Body mass index is an imperfect measure of surgical risk in this population, partly due to volume overload and variable visceral adiposity. Weight loss before transplantation may be beneficial, but it remains important to avoid protein calorie malnutrition and sarcopenia. Intensive lifestyle modifications appear to be successful in achieving weight loss, though the durability of these interventions is not known. Pretransplant and intraoperative bariatric surgeries have been performed, but large randomized controlled trials are lacking. Traditional cardiovascular comorbidities are more prevalent in obese individuals and remain the basis for pretransplant cardiovascular evaluation and risk stratification. The recent US liver transplant experience demonstrates comparable patient and graft survival between obese and nonobese liver transplant recipients, but obesity presents important medical and surgical challenges during and after transplant. Specifically, obesity is associated with an increased incidence of wound infections, wound dehiscence, biliary complications and overall infection, and confers a higher risk of posttransplant obesity and metabolic syndrome-related complications. In this review, we examine current practices in the obese liver transplant population, offer recommendations based on the currently available data, and highlight areas where additional research is needed.

DOI10.1097/TP.0000000000001794
Alternate JournalTransplantation
PubMed ID28930104
PubMed Central IDPMC5762611
Grant ListK23 AG048337 / AG / NIA NIH HHS / United States

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