Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina.
| Title | Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Ziakas, A., Gavrilidis S., Souliou E., Giannoglou G., Stiliadis I., Karvounis H., Efthimiadis G., Mochlas S., M Vayona A., Hatzitolios A., Savopoulos C., Pidonia I., & Parharidis G. |
| Journal | Angiology |
| Volume | 60 |
| Issue | 1 |
| Pagination | 50-9 |
| Date Published | 2009 Feb-Mar |
| ISSN | 1940-1574 |
| Keywords | Adult, Aged, Aged, 80 and over, Angina, Unstable, Biological Markers, C-Reactive Protein, Cardiovascular Diseases, Ceruloplasmin, Female, Fibrinogen, Follow-Up Studies, Hospitalization, Humans, Interleukin-6, Male, Middle Aged, Predictive Value of Tests, Prognosis, Severity of Illness Index, Time Factors, Troponin T, Up-Regulation |
| Abstract | BACKGROUND: We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina.METHODS: All 4 substances were measured on admission and after 6, 12, 24, 48, and 72 hours, and after 7 days and 6 months in 40 patients with Braunwald's classification class IIIB unstable angina.RESULTS: All recorded substances increased significantly; 15 patients had cardiovascular events during hospitalization and 11 patients during follow-up. The time course and the mean values of Fib, CRP, and IL-6 were similar in patients with and without complications both during hospitalization and follow-up. However, CP levels from 6 hours until 6 months were significantly higher in patients with complications during follow-up (P < .05).CONCLUSIONS: Fib, CRP, IL-6, and CP levels alter in patients with severe unstable angina. However, only CP levels were related to 12-month follow-up prognosis. |
| DOI | 10.1177/0003319708314249 |
| Alternate Journal | Angiology |
| PubMed ID | 18388036 |
